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Sudhakar, Muvvala
- Formulation and Optimization of Porous Osmotic Pump Based Controlled Release System of Ritonavir for the Treatment of HIV Infection
Abstract Views :454 |
PDF Views:2
Authors
Chinmaya Keshari Sahoo
1,
Surepalli Ram Mohan Rao
2,
Muvvala Sudhakar
3,
D. Venkata Ramana
4,
K. Satyanarayana
5
Affiliations
1 Department of Pharmaceutics, Faculty of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana - 500007, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana - 500014, IN
4 Department of pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana - 508252, IN
5 Department of Pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R.R. District, Telangana - 500088, IN
1 Department of Pharmaceutics, Faculty of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana - 500007, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana - 500014, IN
4 Department of pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana - 508252, IN
5 Department of Pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R.R. District, Telangana - 500088, IN
Source
Asian Journal of Pharmacy and Technology, Vol 8, No 1 (2018), Pagination: 13-22Abstract
The current research involves the development of controlled porosity osmotic pump (CPOP) tablets of ritonavir for the treatment of HIV infection. Core tablets were prepared by wet granulation method using hydroxyl propyl methyl cellulose (HPMCE5LV) polymer, mannitol as osmogen, MCC as diluents and other additives. The CPOP tablets were coated with cellulose acetate as wall forming material, poly ethylene glycol as flux regulating agent, and sorbitol acts as pore forming material in SPM. The prepared tablets were evaluated for FTIR, DSC, precompression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. The optimized formulation RM5 showed 94.83% at the end of 14 hrs with zero order drug release. The difference factor (f1) and similarity factor (f2) for RM5 were observed 14.61 and 75.12 respectively. Optimized formulation did not show any significant change on the pH and agitation intensity, but it depends on osmotic pressure of dissolution media indicated that mechanism of drug release was due to osmotic pressure. SEM micrographs confirmed that no pores were found before dissolution and after dissolution had shown the porous nature of the membrane. Short term stability study at 40 ± 2 °C/75 ± 5% RH for three months on the RM5 formulation indicated that there was no significant change weight variation, %friability, drug content and in vitro drug release.Keywords
Ritonavir, Wet Granulation, CPOP, Difference Factor, In Vitro Drug Release, Stability Study.
References
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- Sahoo CK, Sahoo NK, Rao SRM, Sudhakar M, Satyanarayana K. A review on controlled porosity osmotic pump tablets and its evaluation Bulletin of Faculty of Pharmacy, Cairo University 2015; 53 (2):195-205.
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- Sahoo CK, Rao SRM, Sudhakar M., and Shashikala P. Formulation and Optimization of Controlled Porosity Osmotic Pump Tablets of Ritonavir, Journal of Chemical and Pharmaceutical Sciences 2017; 10(3): 1345-1352.
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- Sanjay Bajaj, Dinesh Singla and Neha Sakhuja, Stability Testing of Pharmaceutical Products, Journal of Applied Pharmaceutical Science 02 (03); 2012: 129-138.
- Sahoo CK, Rao SRM, and Sudhakar M. Controlled Porosity Osmotic Pump Tablets of Zidovudine and Lamivudine Combination: Optimization and Characterization. Research Journal of Pharmaceutical Dosage Forms and Technology 2017; 9(3):114-122.
- Formulation and Evaluation of Mucoadhesive Buccal Tablets of Resperidone
Abstract Views :149 |
PDF Views:0
Authors
Affiliations
1 Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University, IN
1 Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 1 (2022), Pagination: 13-19Abstract
The aim of present study was to formulation and evaluation of Mucoadhesive buccal tablets of Resperidone. Mucoadhesive buccal tablets of Resperidone were prepared by direct compression method using polymers such as Karaya gum, tamarind gum, carbopol, and Sodium carboxy methyl cellulose. The Buccal tablets were evaluated for various physical, drug content uniformity, in-vitro drug release and drug- excipient interactions (FT-IR). FT-IR spectroscopic studies indicated that there were no drug-excipient interactions. The formulation F9 (containing 30mg of Carbopol) were found to be best formulation, which showed maximum drug release within 8 h. These formulations have showed good bioadhesion strength (18 gm).Keywords
Risperidone, Mucoadhesive Buccal Tablets, Carbopol, Karaya Gum, and Sodium Carboxy Methyl CelluloseReferences
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